Dear Valued Customer, We are thrilled to share some exciting news with you! At Reapian Corporation, we are continuously striving to innovate and enhance our product offerings. We are currently in the process of crafting a new generation of supplements that will further support your health and well-being. Crafting the Next Generation of Supplements As we stand on the brink of a new era, we are called to pioneer the next generation of supplements. This is not just about creating products, but about shaping a future where health and wellness are within everyone’s reach. We are not just formulating supplements, we are crafting catalysts for change. Each capsule, each tablet, each powder is a testament to innovation, a beacon of hope, and a step towards a healthier world. We are not just making supplements, we are making history. So let’s embrace this journey with courage, determination, and the unwavering belief that we can and will revolutionize the landscape of health and wellness. The future is in our hands, and it’s time to make it extraordinary. Let’s pioneer together, for the health of generations to come. While we work on these groundbreaking products, we want to remind you that our current range of supplements is readily available. You can explore and purchase these products in our online shop or find them listed on our reseller pricelist if you are a reseller stockist. To stay informed about our upcoming products and the latest developments within Reapian Corporation, we encourage you to subscribe to our newsletter. By subscribing, you'll receive exclusive updates, special offers, and valuable insights into our newest innovations. Thank you for your continued trust and support. We are committed to providing you with the highest quality supplements to help you achieve your health goals. Reapian Biotechnology Corporation | reapian.com

TRUNAD+ Natural NAD+ Health Booster TRUNAD+ from Reapian Medical is a comprehensive combination of the most powerful nutrients know to science to protect cellular resilience and regeneration of vital NAD+ levels. The unique combination of nutrients in TRUNAD+ have powerful properties to prevent the accumulation of NAD+ consuming cellular damage from 3 major reasons Senescent cells Senescent cells are cells that have stopped dividing and have entered a state of permanent growth arrest, but they remain metabolically active. This state can be triggered by various factors, including telomere shortening, DNA damage, oxidative stress, and oncogene activation. The cells secrete cytokines that damage surrounding cells and cause inflammation. CD-38 Enzymes These enzymes increase as we age and consumes more and more NAD+ as we age. It is like an old engine consuming more and more ol over time. Chronic Inflammation Inflammation increase cellular DNA damage. NAD= is then required to repair the damaged DNA through sirtuin enzyme activity. The Science of NAD+ Every cell in your body is fueled by NAD+ "Think of NAD+ as the fuel that powers your 37.2 trillion cells, keeping your body energized and in tip-top shape. As we age, and with the hustle and bustle of life, our NAD+ levels can take a hit. That's why it's so important to replenish those levels to keep your cells healthy, your energy up, and your vitality shining bright." TRUNAD vs other NAD+ supplements ​ The combination of several key nutrients into ONE powerful supernutrient complex gives Medical TRUNAD+ superior efficacy and makes it more cost-effective and convenient for users. It is taken only Once-a-Day. Other common NAD+ supplements need to be taken multiple times during the day.   Here are a few key points to consider   1. Formulation  TRUNAD uses a unique formulation that includes additional ingredients to enhance the absorption and effectiveness of NAD+. This can lead to faster and more noticeable results compared to other supplements.   2. Bioavailability  TRUNAD is designed to have higher bioavailability, meaning more of the active ingredient is absorbed and utilized by the body. This can make it more effective in boosting NAD+ levels.   3. Additional Benefits  TRUNAD often includes other beneficial compounds, such as antioxidants and anti-inflammatory agents, which can provide additional health benefits beyond just increasing NAD+ levels    4. User Reviews  Many users report better overall results and satisfaction with TRUNAD compared to other supplements - ref. Revgear  Reapian Biotechnology Corporation | reapian.com

The Science of NAD+ Every cell in your body is fueled by NAD+ "Think of NAD+ as the fuel that powers your 37.2 trillion cells, keeping your body energized and in tip-top shape." TRUNAD vs other NAD+ supplements The combination of several key nutrients into ONE powerful super-nutrient complex makes Medical TRUNAD+ superior and more cost-effective for users.    Here are a few key points to consider   1. Formulation   TRUNAD uses a unique formulation that includes additional ingredients to enhance the absorption and effectiveness of NAD+. This can lead to faster and more noticeable results compared to other supplements.   2. Bioavailability  TRUNAD is designed to have higher bioavailability, meaning more of the active ingredient is absorbed and utilized by the body. This can make it more effective in boosting NAD+ levels.   3. Additional Benefits   TRUNAD often includes other beneficial compounds, such as antioxidants and anti-inflammatory agents, which can provide additional health benefits beyond just increasing NAD+ levels    4. User Reviews  Many users report better overall results and satisfaction with TRUNAD compared to other supplements  - ref. Revgear

​REAPIAN MEDICAL PURE MARINE COLLAGEN COMPLEX is a 100% marine-based, all-natural ingredient composed of collagen and elastin peptides formulated in the same ratio found naturally in human skin. PURE MARINE COLLAGEN Unflavored REAPIAN MEDICAL PURE MARINE COLLAGEN COMPLEX is a 100% marine-based, all-natural ingredient composed of collagen and elastin peptides formulated in the same ratio found naturally in human skin. Previous Item Next Item SCHEDULING STATUS [S0] PROPRIETARY NAME AND DOSAGE FORM PURE MARINE COLLAGEN PEPTIDES TYPE I & II (POWDER) Sourced from Wild Caught Cod. Collagen peptides that are absorbed a 150% more efficiently into the body Provides superior bioavailability for superior results For maximum collagen replenishment and connective tissue health Pescatarian friendly INDICATIONS REAPIAN MEDICAL PURE MARINE COLLAGEN COMPLEX is a 100% marine-based, all-natural ingredient composed of collagen and elastin peptides formulated in the same ratio found naturally in human skin. It combines the two main constituents of the extracellular matrix and has an anti-wrinkle synergistic action: elastin fibers give the dermis suppleness that complements collagen fibers' tensile strength. A study showed a synergistic anti-wrinkle action, stimulating the skin to lift and tone sagging areas and minimize lines and wrinkles while increasing skin moisture retention. With a low molecular weight, it is water-soluble and fully digestible, making it an ideal anti-aging ingredient for a wide variety of beauty-from-within applications. Pure Marine Collagen delays the skin aging process by protecting the skin and stimulating its main structural constituents. HELPS REDUCE DEEP WRINKLES Pure Marine Collagen and elastin oligopeptides stimulate the biosynthesis of the main dermis constituents to lift and tone slacking areas. Researchers used a Skin Image Analyser® (S.I.A.) (Monaderm, Monaco) to measure the number and depth of wrinkles. Skin hydration was measured as well. Questionnaires were used throughout the clinical study and showed excellent tolerance to pure marine collagen. After 28 days, marine collagen supplementation resulted in a significant decrease (19%) in the number of deep wrinkles in 71% of the subjects. The level was stabilized on day 84. In the placebo group, an increase in the number of deep wrinkles was noted on both day 28 and day 84. In addition, supplementation caused a moisturizing effect on the skin. COLLAGEN REINFORCES SKIN HYDRATION The moisturizing effect of Marine Collagen is supported by a clinical study involving 44 women over 40 years old. The results show an increase in the entire epidermis hydration (+8%) after oral administration of pure marine collagen for three months, stabilized at day 84. In the placebo group, an increase in the number of deep wrinkles was noted on both day 28 and day 84. In addition, Collagen caused a moisturizing effect on the skin. PRODUCT INFORMATION For more product information - view product documentation here . Scan the QR code for quick and easy product information, as well as guidelines to give your body the boost it deserves.- DIRECTIONS Take 1 (one) level scoop daily, preferably with breakfast as a dietary supplement. You may add to your favorite smoothie, cake or pudding recipe, milkshake, protein or nutrition shake to increase daily collagen requirements. Please consult a health professional before taking any dietary supplements. NAME AND ADDRESS OF THE HOLDER OF CERTIFICATE OF REGISTRATION Reapian Holdings (Pty) Ltd, Reg no. 2022/461302/07. Visit www.reapian.com for more information or send an email to medical@reapian.com DATE OF PUBLICATION 01 June 2022 © Reapian Holdings PURE HYDROLYZED MARINE COLLAGEN PEPTIDES Use as a dietary supplement. Please follow the instructios of use carefully. BUY NOW > BACK TO FORMULARY > Log In

TRUNAD+ Defends Your Cells’ Health & Boosts NAD+. Support your cellular health with TRUNAD+, the most efficient and safest way to elevate the NAD+ levels in your body. TRUNAD+ Age Better TRUNAD+ Defends Your Cells’ Health & Boosts NAD+. Support your cellular health with TRUNAD+, the most efficient and safest way to elevate the NAD+ levels in your body. Previous Item Next Item SCHEDULING STATUS [S0] PROPRIETARY NAME AND DOSAGE FORM TRUNAD+ AGE BETTER LIFELONG LONGEVITY 60 CAPSULES INDICATIONS Reapian Medical TRUNAD+ is a supplement that is formulated with the most scientifically studied and clinically aligned supernutrients that target the 37 trillion plus cells in your body to elevate your NAD levels. Scan the QR code for quick and easy product information, as well as guidelines to give your body the boost it deserves. DIRECTIONS Always take 1 (one) serving 30 minutes before bedtime. Another serving may be taken in the morning with breakfast if you are aged 60+, or depending on your personal needs. Always consult a health professional before taking any supplements. Use at your own risk as a dietary supplement. A fundamental requirement to develop a truly effective NAD supplement is an in-depth understanding of the biochemistry of Telomeres and the role they play in controlling metabolic processes in the human body. Our team of scientists has identified and developed a method how to perform extractions to amplify and quantify Telomere lengths in your chromosomes from dry blood spot samples as part of the 360 Health Protector Program - visit reapian.com for more information. TRUNAD+ Defends Your Cells’ Health & Boosts NAD+. Backed by numerous published research studies, the combination of supernutrients in TRUNAD+ is foundational to improving your cellular health. It is data drive medical technology and the TRUNAD+ supernutrient complex is a gold standard NAD+ booster formula with patented hydroxycinnamic acid extracts. NAD+ is vital for supporting basic cellular functions necessary for you to live. NAD+ is vital to cells’ normal function and resilience. Support your cellular health with TRUNAD+, the most efficient and safest way to elevate the NAD+ levels in your body. WHAT TO EXPECT Promoting cellular health can have many positive effects on your daily routine. It will assist with everything from sustained energy throughout the day to overall improvements in general well-being. Each experience is different because each person is different. Ultimately, what you feel and how long it takes depends on your cells' needs. TRUNAD+ is clinically aligned to significantly elevate cellular NAD levels. TRUNAD+ is targeted to increase your NAD levels. The ingredients are backed by multiple published and ongoing clinical trials**. The addition of the patented CurCousin Calebin A Extract to the formula has numerous health-advancing benefits. It has been shown to play a vital role in the down-regulation of the expression of proteins involved in tumor cell survival, proliferation, inflammation, and metastasis. It thus plays a major role in preventing the spread of cancer. Furthermore, Calebin A inhibited the growth and induced the death of a wide variety of tumor cells, as examined by various assays. It also enhanced apoptosis (the death) of cancer cells induced by chemotherapeutic agents, showcasing it to be a very effective cancer-preventing agent**. The unique combination of ingredients provides the cells with more NAD+, giving them more fuel, and more energy. Your cells will function much better, live much longer, and stay healthy. This elevated NAD+ greatly improves the body's ability to reduce its circulating free radical load. By decreasing free radicals in the body, leads to less inflammation and thus premature aging and death of cells. TRUNAD+ Complex also increases the levels of Glutathione, the most important endogenous antioxidant in the human body. Certain amino acids included in TRUNAD+ Complex have proven anti-aging effects on cells as well as collagen protection and thus skin anti-wrinkle benefits. It also helps to activate enzymes involved in the detoxification of the liver but may provide protection against metal toxicity and skin damage by ultraviolet exposure. Resveratrol plays a vital role in Phase ll liver detoxification, as well as numerous other advantages. The TRUNAD+ Complex also has beneficial effects on blood sugar and weight regulation**. VITAMIN B3 as a key nutrient: Pirinen et al. report that niacin, a vitamin B3, can efficiently rescue NAD+ levels in the muscle and blood of patients with mitochondrial myopathy, improving disease signs and muscle strength. NAD+ levels increased also in healthy subjects. FREQUENTLY ASKED QUESTION Why does TRUNAD+ NOT contain NAD and/or NMN as individual compounds in the formula? It was reported in the Journal of Nutrition that NAD and NMN were digested in the digestive juices, they accumulated but were not absorbed. It is therefore not sensible to add it as a direct compound to a NAD supplement to elevate NAD levels. A number of biochemical pathways were consulted and the most lucrative combination of nutrients to be most effective, from intestinal digestion to intracellular metabolism for the elevation and rescue of NAD+ levels, was included in the TRUNAD formulation. A number of preparations of varying complexity have been used in an effort to elucidate the reactions by which NAD is hydrolyzed to nicotinamide during intestinal digestion. NAD labeled with 14C in the adenine or pyridine moiety was the substrate used with perfused rat intestine, live rats, and perfused live rats, with a collection of portal flow, intestinal contents, mucosal tissue, or pancreatic juice. The conclusions reached are that a pyrophosphatase present in the intestinal juice and to a much lesser extent in the pancreatic juice releases 5'-AMP and nicotinamide ribonucleotide. The 5'-AMP was rapidly converted to adenosine and then to inosine by bacteria-free intestinal contents. Perfused or intact intestine rapidly hydrolyzed NMN to nicotinamide riboside, which accumulated, but was not absorbed. It was slowly cleaved by an enzyme associated with the mucosal cells to nicotinamide, which was the major if not the only labeled compound absorbed. Health and age-related conditions that TRUNAD+ help to address are: Epigenetic distortions Altered intercellular communication Deregulated nutrient sensing Telomere shortening Metabolic imbalance Sperm activity and motility Stem cell exhaustion Loss of proteostasis Cellular senescence Restful Sleep PRODUCT INFORMATION For more product information - view product documentation. REFERENCES PubMed research article, please see product documentation. NAME AND ADDRESS OF THE HOLDER OF CERTIFICATE OF REGISTRATION Reapian Holdings (Pty) Ltd, Reg no. 2022/461302/07. Visit www.reapian.com for more information or send an email to medical@reapian.com DATE OF PUBLICATION 27 September 2022 © Reapian Holdings BUY NOW > BACK TO FORMULARY > Log In

Reapian Medical SPORT XSPN BCAA Xstreme Amino Boost contains all nine essential amino acids including branched chain amino acids , three conditionally essential amino acids, three non-essential amino acids, and citrulline to boost your daily amino acid intake and boost nitric oxide production. It is fortified with folate to make it a superior, complete, and unique amino acid supplement. XSPN BCAA Xstreme Amino Boost Reapian Medical SPORT XSPN BCAA Xstreme Amino Boost contains all nine essential amino acids including branched chain amino acids , three conditionally essential amino acids, three non-essential amino acids, and citrulline to boost your daily amino acid intake and boost nitric oxide production. It is fortified with folate to make it a superior, complete, and unique amino acid supplement. Previous Item Next Item SCHEDULING STATUS [S0] PROPRIETARY NAME AND DOSAGE FORM XSPN BCAA XSTREME AMINO BOOST POWDER INDICATIONS Reapian Medical SPORT XSPN BCAA Xstreme Amino Boost contains all nine essential amino acids including branched chain amino acids (tryptophan, isoleucine, leucine, valine, methionine, threonine, histidine, phenylalanine, lysine), three conditionally essential amino acids (arginine, glycine, glutamine), three non-essential amino acids (asparagine, glutamate, serine), and citrulline to boost your daily amino acid intake and boost nitric oxide production. It is fortified with folate to make it a superior, complete, and unique amino acid supplement. Scan the QR code for quick and easy product information, as well as guidelines to give your body the boost it deserves. DIRECTIONS Take 1 (one) level scoop daily, preferably in the morning with breakfast. Add to your favorite smoothie, protein or nutrition shake to increase daily amino acid requirements. Please consult a health professional before taking any dietary supplements. WHAT TO EXPECT BCAA’s or branched-chain amino acids have been a staple for many who are looking to boost their exercise performance & recovery. They have a molecular structure that includes a branched chain, hence the name. This structure allows them to bypass organs such as the liver and be quickly digested and metabolized into muscle tissue. BCAA’s consist of just 3 of the 9 Essential Amino Acids. They are Leucine, Valine & Isoleucine. Leucine is responsible for Muscle Protein Synthesis (the process in which cells make proteins and the body maintains & builds muscle). It also helps to regulate blood sugar levels, stimulates wound healing, and produces growth hormones. Valine also helps to stimulate muscle growth, stimulate muscle regeneration and is involved in the process of energy production. Isoleucine is involved in muscle metabolism, which is the energy consumption by all cells, including those of muscle tissue, to perform work. Isoleucine is heavily concentrated in the muscle tissue and is also responsible for hemoglobin production and energy regulation. On the surface it would seem that these 3 BCAAs are both beneficial to us & important when It comes to building muscle, increasing exercise performance & optimizing recovery. However, what many don’t know is that taking BCAA’s in isolation from all the other Essential Amino Acids makes them ineffective for building muscle, but also may lead to an amino acid imbalance and other adverse side effects. This leads us to the point that if the body has excess BCAA’s, it will break down its own muscle tissue to free up the other six Essential Amino Acids and bring back a balance. This is the reason why you should not take BCAA’s in isolation from the other six Essential Amino Acids. The three BCAAs - Leucine, Valine & Isoleucine are effective when taken in an optimal formula with all other EAAs, this allows them to be processed and used by the body in a much more natural, effective manner. To make the formula superior and most scientifically aligned, it is fortified with folate to make it a complete, and unique amino acid supplement. PRODUCT INFORMATION For more product information, please view the documentation. NAME AND ADDRESS OF THE HOLDER OF CERTIFICATE OF REGISTRATION Reapian Holdings (Pty) Ltd, Reg no. 2022/461302/07Visit www.reapian.com for more information or send an email to medical@reapian.com DATE OF PUBLICATION 11 November 2022 © Reapian Holdings BUY NOW > BACK TO FORMULARY > Log In